Redox control of vascular smooth muscle cell function and plasticity
نویسندگان
چکیده
منابع مشابه
Redox regulation of vascular smooth muscle cell differentiation.
Experiments were performed to determine the role of reactive oxygen species (ROS) in regulating vascular smooth muscle cell (VSMC) phenotype. After quiescence, cultured human VSMCs increased their expression of differentiation proteins (alpha-actin, calponin, and SM1 and SM2 myosin), but not beta-actin. ROS activity, determined using the H(2)O(2)-sensitive probe dichlorodihydrofluorescein (DCF)...
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O xidative stress and the production of intracellular reactive oxygen species (ROS), such as superoxide (O2 ), hydrogen peroxide (H2O2), and hydroxyl radical (OH), have been implicated in the pathogenesis of cardiovascular disease, in part by promoting vascular smooth muscle proliferation. Within the vessel wall, ROS are generated by several mechanisms, including vascular NAD(P)H oxidases. 6 RO...
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Differentiated vascular smooth muscle cells (SMCs) retain the capacity to modify their phenotype in response to inflammation or injury. This phenotypic switching is a crucial component of vascular disease, and is partly dependent on epigenetic regulation. An appreciation has been building in the literature for the essential role chromatin remodelling plays both in SMC lineage determination and ...
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In the past several years, a significant body of work has been published in ATVB about new research in the field of vascular biology and redox signaling. We would like to highlight new publications that have enriched our understanding of redox signaling in the context of vasculopathy. Although redox balance and perturbation involve a plethora of proteins and signaling molecules, the focus of re...
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C ellular plasticity has become the subject of intense research, with perhaps the greatest example provided by the recent Nobel Prize winners Drs Yamananka and Gurdon and the demonstration that terminally differentiated fibro-blasts can be coaxed into assuming an embryonic stem cell-like fate. Emerging evidence suggests that plasticity inherent in cells may be hijacked in the progression of dis...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2018
ISSN: 0023-6837,1530-0307
DOI: 10.1038/s41374-018-0032-9